We’ve recently been diving into some whole-genome data sets from rare disease cohorts, and we keep encountering variants in untranslated regions — particularly the 5’ and 3’ UTRs — that are flagged as potentially interesting but difficult to interpret. Most annotation tools still underplay the importance of UTRs, despite growing evidence of their role in gene regulation, mRNA stability, and translation efficiency. The real challenge is contextualizing these variants in terms of their position relative to functional motifs or overlapping regulatory elements. I’m wondering how others here are tackling this. Are you treating UTR variants with more weight than before? And if so, what resources or visualization strategies are helping you make that judgment with more confidence?